Choose wisely! One of the common prejudices passed down generation to generation is that in which apparently it does not matter where you are working as long as you are working.
Truth is, it does matter. It is [still] important in the world of brands where your base is [even if you outsource the cad-monkey section], and where your work is based.
If you act within a top city, you get buzz and attention a lot faster. That will allow you to contact people who are worth working with, and will enjoy moving near. The quality of your work is as strong as it's worst team member.
Think strategically, not only practically, if where you are is going to help you get where you want. If not, dare to MOVE! You can't stand still or the world will pass you by in a heartbeat.
If you are not taking advantage of the city, be certain the city will take over you & your work. Just as the city can enable, it can destroy!